BIO SOLUTIONS
4M Hyaluronic Acid / PCA / Dermo Filler Complex
METHYLENE BLUE
Methylene Blue is a remarkably powerful antioxidant that neutralizes harmful free radicals, unstable molecules that accelerate aging. It also enhances the function of mitochondria, the energy powerhouse of skin cells, by boosting ATP (adenosine triphosphate) production, cells’ essential energy currency needed in skin cell repair and regeneration. Methylene Blue’s unique chemical structure makes it both water—and fat-soluble, allowing it to penetrate deeply into all layers of the skin, enabling it to stimulate the production of collagen and elastin—key proteins that give skin its firmness, elasticity, and vitality. Many studies have demonstrated that Methylene Blue can reverse signs of skin damage by optimizing cellular function, increasing hydration, and thickening the dermis, the skin’s supportive middle layer.
HYALURONIC ACID
(HA) is most abundant in the skin, accounting for 50% of the total body HA, and is a crucial molecule for providing structure and volume while also maintaining and attracting moisture. Aging reduces HA, leading to moisture and skin structure loss. Hyaluronic acid with different molecular weights (MW) ensures that the humectant penetrates all layers of the skin, resulting in comprehensive skin hydration.
Research shows that the MW of HA affects skin hydration and wrinkle reduction. High MW (>1.5 Mda) forms a moisture-sealing layer, filling wrinkles. Middle MW (500 kDa—1.5 MDa ) enhances epidermal moisture and repairs damage. Low MW (3-500 kDa) penetrates the dermis, scavenging free radicals and promoting collagen synthesis and wound healing.
Fig.1: Hyaluronic acid activity, molecular weight dependence, and claimed effect of HA. (TEWL— Transepidermal Water Loss; DEJ—Dermoepidermal junction) (Juncan, A. M. et al. (2021))
Pyrrolidone Carboxylic Acid
PCAÂ or its sodium salt (Na-PCA) is an amino acid naturally occurring in the skin with the highest water-binding ability and naturally provides hydration, elasticity, and volume. It also restores disordered lipid structure and improves skin barrier function.
DERMO FILLER
Subcutaneous fatty tissue is responsible for the plump aspect of the face. With age, this fat pad progressively melts due to a disturbance of fatty cell metabolism, resulting in the development of pronounced lines around the nose and mouth, drooping skin around the jawline, and hollow areas beneath the eyes. Dermo Filler is a lipo filling-like alternative that has a new innovative mechanism of action: to stimulate the body’s natural mechanism to increase fatty tissue for facial rejuvenation and a complete anti-aging improvement.
Fig. 2: Reverse effect of Dermo-Filler.


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