BIO SOLUTIONS
4M Hyaluronic Acid / PCA / Dermo Filler Complex
HYALURONIC ACID
(HA) is most abundant in the skin, accounting for 50% of the total body HA, and is a crucial molecule for providing structure and volume while also maintaining and attracting moisture. Aging reduces HA, leading to moisture and skin structure loss. Hyaluronic acid with different molecular weights (MW) ensures that the humectant penetrates all layers of the skin, resulting in comprehensive skin hydration.
Research shows that the MW of HA affects skin hydration and wrinkle reduction. High MW (>1.5 Mda) forms a moisture-sealing layer, filling wrinkles. Middle MW (500 kDa—1.5 MDa ) enhances epidermal moisture and repairs damage. Low MW (3-500 kDa) penetrates the dermis, scavenging free radicals and promoting collagen synthesis and wound healing.
Fig.1: Hyaluronic acid activity, molecular weight dependence, and claimed effect of HA. (TEWL— Transepidermal Water Loss; DEJ—Dermoepidermal junction) (Juncan, A. M. et al. (2021))
Pyrrolidone Carboxylic Acid
PCAÂ or its sodium salt (Na-PCA) is an amino acid naturally occurring in the skin with the highest water-binding ability and naturally provides hydration, elasticity, and volume. It also restores disordered lipid structure and improves skin barrier function.
DERMO FILLER
Subcutaneous fatty tissue is responsible for the plump aspect of the face. With age, this fat pad progressively melts due to a disturbance of fatty cell metabolism, resulting in the development of pronounced lines around the nose and mouth, drooping skin around the jawline, and hollow areas beneath the eyes. Dermo Filler influences the transformation of pre-fatty cells into fatty cells, activates fatty acids synthesis, and inhibits the breakdown of lipids into free fatty acids.
Fig. 2: Reverse effect of Dermo-Filler.
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