Fisetin and Its Benefits on Well-Being - Asya Grafy Bio Institute
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Fisetin and Its Benefits on Well-Being

Fisetin and Its Benefits on Well-Being

There is an increasing number of studies on phytochemicals that positively impact our health. Until recently, a very powerful flavonoid – fisetin – was relatively little studied regarding its impressive effects on human health. The highest amounts of fisetin can be found in strawberries and apples. Many studies have published results on the anti-inflammatory, antioxidant, anticancer, and senolytic properties of fisetin, making it a valuable ally in the fight against aging and chronic diseases. Discover how fisetin can contribute to your health and uncover the latest findings that could change the way we think about natural supplements.

  1. What is Fisetin?

Chemical Structure of Fisetin1

Fisetin is a natural flavonoid. Flavonoids belong to the group of polyphenols, which are abundant in plant-based foods. The medicinal effects of fisetin, due to its important biological functions, have recently increased its popularity. The highest concentrations have been recorded in strawberries (160 mg/g), apples (26.9 mg/g), and persimmons (10.5 mg/g), and it is also found in mangoes, kiwis, and some types of vegetables such as onions and cucumbers. In 2018, studies showed that fisetin is one of the most potent senolytics – compounds that can selectively remove old or damaged cells. This discovery has attracted significant scientific attention for further research.

  1. How Does Fisetin Work in the Body?

Fisetin exerts its health benefits in the body through various mechanisms of biological action. It removes free radicals and reduces oxidative stress, which can damage cells and cause chronic diseases. Fisetin will also protect cellular lipids, proteins and DNA components from oxidative damage due to scavenging of these reactive oxygen species. It also exhibits significant anti-inflammatory properties. It works by inhibiting the activities of pro-inflammatory enzymes and cytokines, thereby suppressing inflammation. This double action as an antioxidant and anti-inflammatory agent makes fisetin very effective in the prevention and treatment of aging and chronic diseases. Furthermore, fisetin has been found to induce apoptosis in cancer cells, trigger neuroprotection and improve overall cell health. It also acts in neuroprotection and reduces inflammation in the brain. It promotes the growth of brain cells and maintains them, thereby improving cognitive functions in the form of memory and learning. Another protective role fisetin has for the brain is through its antioxidant properties against oxidative stress in neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

  1. The Health Benefits of Fisetin
  1. Anti-Inflammatory and Antioxidant Benefits

One of the most notable properties of fisetin is its antioxidant capacity. Antioxidants are crucial in combating oxidative stress, a condition linked to chronic diseases such as cancer and heart disease. Fisetin’s antioxidant properties have been demonstrated in numerous studies, showing its potential in neutralizing harmful free radicals in the body. In addition to its antioxidant capabilities, fisetin also exhibits anti-inflammatory properties. Inflammation is a natural response of the body to injury or infection. However, chronic inflammation can lead to various health problems, including heart disease and cancer. Fisetin has been shown to inhibit the production of inflammatory molecules, thereby reducing inflammation in the body. The antioxidant and anti-inflammatory properties of fisetin are intertwined. Oxidative stress can trigger inflammation, and inflammation can lead to further oxidative stress. By acting as both an antioxidant and an anti-inflammatory agent, fisetin may help break this vicious cycle.

  1. Anti-Aging Properties

Aging is a highly flexible process that can be modulated in a variety of ways, such as caloric restriction, intermittent fasting, exercise, and a plant-based diet rich in phytochemicals. The use of bioactive compounds to eliminate cellular senescence has recently emerged as a promising approach to delay aging and reduce the severity of chronic diseases. It removes senescent cells, cells that have stopped dividing and contribute to aging and tissue dysfunction. By removing these cells, fisetin can improve tissue health and delay the onset of age-related decline. acting as a senotherapeutic agent is capable of extending lifespan, reducing ROS levels and improving antioxidant cellular responses. This neuroprotection has been detected in in vitro and in vivo models associated with various neurological disorders. 

  1. Cognitive Health

Fisetin has been found to decrease inflammation in the brain. Effectively, it is a greater causative factor for diminishing cognitive abilities, and examples of that are neurological diseases alongside reducing inflammation. Fisetin can help to control the healthy inflammatory response by blocking pro-inflammatory enzymes and cytokines and this is very important for the function of your brain. This leads to a related benefit: the survival and growth of brain cells. It increases neurogenesis, the process of new neuron formation in the brain and enhances synaptic plasticity, one of the most important mechanisms behind learning and memory. This neuroprotective effect helps enhance cognitive function, memory recall, learning ability, and overall mental acuity.

  1. Cancer Prevention

Fisetin can connect with several cell-signaling pathways that are engaged in the development of a wide range of human cancers and hence could serve as an excellent candidate for cancer therapy or chemoprevention. The important aspect of fisetin for anti-cancer is the ability to induce both apoptosis and cell proliferation. Also effectively attenuates several molecular targets affiliated with cancer outgrowth thereby imparting anti-cancer effects. Fisetin is able to target these pathways directly, thus repressing tumor growth and potentiating the action of conventional chemotherapeutic agents. In addition to this, it has potential to abate drug resistance for cancer therapy and impact on heart health. 

  1. Fisetin in food

Rich natural benefits containing fisetin come from: Strawberries: packed with approximately 160 g of this source, as part of the serving, constitutes the essential vitamins and minerals required by the human body. Apples: contain approximately 27 g of fisetin and are also rich in fibers and vitamin C. Persimmons: deliver over 11 g of fisetin and better eye health and are very helpful in preventing cancer. Onions contain approximately 5 grams of fisetin and are found in so many foods, and maximal health benefits are found in them when as little of the outer layers as possible are peeled off. Grapes contain more than 4 grams of fisetin and have been shown to kill cellular senescence, thus helping ward off age-related diseases. It can also be taken as a supplement with its dosage adjustable.

  1. Recommended dosage for various health benefits

The recommended dose of fisetin depends on the health status of the individual and the goal to be pursued. The daily dose varies between 100 mg and 500 mg. Doses over 500 mg are used by those who want to take advantage of fisetin’s anti-aging potential. Of course, individual needs differ and the dose is determined according to the current state of health and body weight.The important thing about fisetin as a supplement is that it is a nutritional supplement, not a substitute for a balanced diet and a healthy lifestyle.A healthcare professional should always be consulted before starting any new supplement regimen. 

References

1. Sarı, E. N. & Soysal, Y. Molecular and Therapeutic Effects of Fisetin Flavonoid in Diseases. J. Basic Clin. Health Sci. 4, 190–196 (2020). 

2. Antika, L. D. & Dewi, R. M. Pharmacological aspects of fisetin. Asian Pac. J. Trop. Biomed. 11, 1 (2021). 

3. Bajnath, A. FISETIN: Why are people taking this supplement? The Institute for Human Optimization https://ifho.org/blog-fisetin/ (2021). 

4. Elsallabi, O. et al. Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection. Molecules 27, 738 (2022). 

5. Grynkiewicz, G. & Demchuk, O. M. New Perspectives for Fisetin. Front. Chem. 7, (2019). 

6. Hassan, S. S. ul et al. The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. Front. Pharmacol. 13, (2022). 

7. Imran, M. et al. Fisetin: An anticancer perspective. Food Sci. Nutr. 9, 3–16 (2021). 

8. Kashyap, D. et al. Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy. Life Sci. 194, 75–87 (2018). 

9. Khan, N., Syed, D. N., Ahmad, N. & Mukhtar, H. Fisetin: A Dietary Antioxidant for Health Promotion. Antioxid. Redox Signal. 19, 151–162 (2013). 

10. Kumar, R. et al. FISETIN: A PHYTOCHEMICAL WITH VARIOUS PHARMACOLOGICAL ACTIVITIES.  Plant Arch. 19, 1012–1016 (2019). 

11. Naeimi, A. F. & Alizadeh, M. Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies. Trends Food Sci. Technol. 70, 34–44 (2017). 

12. Rahmani, A. H., Almatroudi, A., Allemailem, K. S., Khan, A. A. & Almatroodi, S. A. The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. Molecules 27, 9009 (2022). 

13. Ravula, A. R. et al. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. Eur. J. Pharmacol. 910, 174492 (2021). 

14. Yamaura, K. et al. The effects of fisetin on bone and cartilage: A systematic review. Pharmacol. Res. 185, 106504 (2022). 

15. Fisetin: A Potent Flavonoid for Healthspan and Age Defying Benefits – NMNBIO. https://nmnbio.co.uk/blogs/supplements/fisetin

16.The benefits of Fisetin supplements. Charava MENA https://www.charava.ae/blogs/latest/the-benefits-of-fisetin-supplements

17.What is Fisetin? Benefits, Dosage, and Risks. https://vitality-pro.com/fisetin/benefits-dosage-side-effects-fis/

18.What are the Health Benefits of Fisetin? livenaturalproducts   https://livenaturalproducts.com/blogs/news/what-are-the-health-benefits-of-fisetin (2023).   

19.Fisetin: Benefits, Dosage and Side Effects. NMNBIO https://nmnbio.co.uk/blogs/supplements/fisetin-benefits-dosage-and-side-effects (2024).  

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